A downed plane over the Great Lakes sends Abby's world into a tailspin. Romano's surgical career is altered forever, a teen is suspected of intentionally running down her classmates, Weaver gets a promotion from a grateful alderman, and a terminal patient helps Lewis weigh the pros and cons of a blind date while she handles a case where an unpopular student either mistakenly or deliberately ran down her classmates. Meanwhile, Pratt has an unexpected reaction to Chen's revelation about her baby.