Season 3 premiere. As Pope Alexander (Jeremy Irons) fights for his life after being poisoned, the Cardinals jockey for position to take over the Papacy. Cesare (Francois Arnaud) and Micheletto (Sean Harris) trace the assassination plot back to its source, but Della Rovere (Colm Feore) is ready to make his move. Catherina Sforza (Gina McKee) dispatches her own personal assassin, Rufio (Thure Lindhart), to dethrone the Borgias. However, thanks to Lucrezia's (Holliday Grainger) quick thinking, the family's grip on power may not be lost.