"Boss" centers on the Machiavellian machinations of a fictional Chicago mayor with a dark secret. Joining Grammer, who will be making his first dramatic TV series debut as Chicago Mayor Tom Kane, in the main cast on "Boss" are Connie Nielsen (Gladiator, The Devil's Advocate) as his wife Meredith, a formidable Chicago power in her own right; Jeff Hephner ("The O.C.," "Hellcats," "Easy Money") as ambitious young politician Alex Zajac; Hannah Ware (Cop Out) as the Kanes' estranged daughter Emma; and Kathleen Robertson ("Girls Club," "Beverly Hills, 90210," Hollywoodland) as Mayor Kane's supremely organized aide Kitty O'Neil.