Two men were arrested in West Hartford, Connecticut over allegations they tried to buy two $1,000 (GBP625) flatscreen TVs from a local electronics store last year using the 50 Cent's American Express number, according to the New York Daily News.
The pair was detained by cops after the store owner became suspicious and called the credit card company.
The publication reports there have been other attempts to illegally use 50 Cent's card details in two other towns in Connecticut, as well as in New York.
Defence attorney, Frank Canace, who is representing one of the men arrested, refused to comment as the case is still pending.
An American Express spokeswoman tells the New York Daily News, "(We) will not hold our card members liable for any fraudulent charges."