The 'You've Got Mail' actress will also executive produce the comedy about a single mom returning to her New York publishing house only to find that she now works for her former intern.
Meg Ryan has landed her first TV role since her last on-screen series regular role on 1985's short-lived Western series "Wildside". The Golden Globe-nominated actress has signed up to star on a new NBC comedy.
Hailed from "Family Ties" writer and Emmy nominee Marc Lawrence, the single-camera comedy will feature Ryan as a sunny, devoted and desperately non-confrontational single mom who decides to return to her New York publishing house where she was once a brilliant editor to find that she now works for Brenda, her neurotic 30-year-old boss who was once her former intern.
Now Rose must find a way to keep her boss, her teenage kids, her almost ex-husband and her meddlesome mother-in-law all happy, which results in her overcomplicating every situation and somehow always making it worse.
Ryan and Lawrence will also executive produce the yet-to-be-titled project alongside Ryan's manager Jane Berliner. NBC has ordered the pilot for the half-hour comedy.
Ryan had a co-starring role on NBC's 1982 sitcom "One of the Boys", which only lasted 13 episodes. Her last scripted TV series appearance was in season 7 of "Curb Your Enthusiasm", in which she played herself.
Earlier this month, another film star Halle Berry made a commitment to headline CBS' drama "Extant" from executive producer Steven Spielberg. The futuristic thriller has received a straight-to-series order for a 2014 summer premiere.