Barney Stinson and the gang will show up at the convention July 20, while 'Glee' will be sitting out the annual event this year after participating in the last four years.
Before it ends its run, "How I Met Your Mother" will head to San Diego Comic-Con for the first time. Twentieth Century Fox Television has announced that the sitcom, which will enter its final season this fall, will take part in the summer convention this year.
The main cast members, Josh Radnor, Jason Segel, Cobie Smulders, Neil Patrick Harris and Alyson Hannigan, are set to attend the show's panel on Saturday, July 20, joined by executive producers Carter Bays, Craig Thomas and Pamela Fryman. An exclusive look at the show will be screened.
Regular participants, such as "Sons of Anarchy", "Bones", "Family Guy", "The Simpsons", "Bob's Burgers" and "American Dad!" will make return appearances. Also brought to the convention this year are new shows likes "Sleepy Hollow" and "Murder Police".
Meanwhile, "Glee" which took part at Comic-Con in the last four years, will skip the event this season. It's worth to be noted though, that the musical series was not included on the original 20th schedule in 2012, but it eventually joined the convention.
20th Century Fox TV's 2013 San Diego Comic-Con Line-Up:
Thursday, July 18
"Murder Police": Panelists include creators David Goodman and Jason Ruiz, as well as voice talent Will Sasso, Chi McBride, Peter Atencio and Justina Machado.
Friday, July 19
"Sleepy Hollow": EPs Alex Kurtzman and Roberto Orci and Len Wiseman will unveil the new project with an exclusive, world premiere screening of the Pilot followed by a Q&A with fans featuring series lead Tom Mison and Nicole Beharie.
"Bones": Creator and EP Hart Hanson, EP Stephen Nathan and star David Boreanaz all return with unseen footage and a Q&A session.
"Bob's Burgers": The entire cast, including H. Jon Benjamin, Dan Mintz, Eugene Mirman, John Roberts, Kristen Schaal and Larry Murphy, will be on hand for the screening and panel.
"Brickleberry": A full new episode of season two will debut with an intro from creators and EPs Waco O'Guin and Roger Black.
Saturday, July 20
"How I Met Your Mother": The very Con-friendly cast - Josh Radnor, Cobie Smulders, Jason Segel, Neil Patrick Harris, Alyson Hannigan - join the EPs for their first ever panel.
"Futurama": Most of the voice cast from the series will be on hand to discuss the resurrected (and re-canceled) cartoon and introduce scenes from the upcoming "Last Episode Ever."
"The Simpsons": The 25-year-old cartoon promises never-before-seen footage from guest director Guillermo del Toro, among other things.
"Family Guy": A season 12 preview is on the schedule, along with Seth Green, Alex Borstein and surprise guests.
"American Dad!": "The American Dad!" panel will include world premiere of a song from the never-before-seen Christmas episode.
Sunday, July 21
"Sons of Anarchy": Creator Kurt Sutter and stars Charlie Hunnam, Katey Sagal, Ron Perlman, Maggie Siff, Kim Coates, Mark Boone Junior, Tommy Flanagan, Theo Rossi, Dayton Callie and Jimmy Smits are all on board for the closing day panel.