The March 26 episode of "Supernatural" takes on an alternate life of Sam and Dean when they are not hunters. They are described as two different but very normal people who don't know each other.
Dean is a corporate man who enjoys health drinks and listens to news radio vs. rock stations. He works at a company called Sandover Bridge & Iron Company alongside Sam who is in Tech Support. It seems as if the two do not know each other. However, after co-workers start committing suicide at an alarming rate, the two find themselves working side by side to solve the murders.
The episode is called "It's a Terrible Life". In its casting call, there will be a character named Mr. Adler, a corporate executive who is later revealed to be "a person with considerable supernatural authority, the kind of fella who can get things done."