In the new 'House M.D.', a boy has a special genetic condition which confuses him of being a girl.
House hides something from his colleagues and is forced to tell the truth after he is found not breathing. In the next episode of "House M.D.", Cuddy and Wilson suspect something is wrong with House when he starts acting way too nice. When they discover the shocking answer, they must face the prospect that House may be changed forever.
Meanwhile, the team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision.
"The Softer Side" airs February 23.