Based on November 6 episode of "Grey's Anatomy" that features Dr. Izzie Stevens being reminded of her deceased fiance, Denny Duquette, which leads to a speculation of Izzie's brain tumor, Shonda Rimes finally gives her comment. To EW's Michael Ausiello, she briefly says that the reason of bringing back Denny in the middle of Izzie and Alex has nothing to do with the deadly disease.
As Rimes states, "I think the love triangle with Denny, Izzie, and Alex is among the most interesting we've ever done. Watching the chemistry between Jeffrey and Katherine again has been really touching." Then she adds, "I can't wait for our viewers to see where we're taking it. But what it won't involve is Izzie having a brain tumor."
On November 6, "Grey's Anatomy" episode 5.07 entitled "Rise Up" features Dr. Izzie having visions of her deceased fiance, Denny Duquette, when a patient was treated with a heart problem. In the upcoming November 20, Denny will appear again in Izzie's flashbacks.
Meanwhile, Ausiello also gives a clue that Sadie, Meredith Grey's oldest friend, will be a future lover for Sara Ramirez's Callie Torres. The news comes after Brooke Smith's Dr. Erica Hahn is getting the axe from "Grey's Anatomy".