Amidst the uncertainty whether he will again direct or simply serve as producer in "Spider-Man 4", Sam Raimi recently indicated in an interview held by ComicBookResources that the project's story is no longer his concern and it's completely up to the writer, in this case surely James Vanderbilt, to work it on now.
"We’re hiring a writer to come up with his own take," Raimi said to the site. "Sony was willing to go either way, we’ll just have to wait and see what the writer comes up with. I think anything’s possible, though."
Furthermore, Raimi even remarked that the premise "doesn’t have to follow the [Spider-Man] movies" while saying "anything's possible" to happen in the movie though he did admit that he would very much like to see Tobey Maguire as the web-slinging superhero again.
"Spider-Man’s such a big character in the comic books that he could endure a lot of different interpretations," he said. "You could start over or you could start with a different aspect of the story than I’ve focused on in the pictures I’ve made, we’ll just have to wait and see what the writer comes up with."