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With an estimated $23.8 million, the crime drama thriller becomes the first directed movie by Affleck that debuts on number one at the chart.
'This new 'Resident Evil' is the first one to ever open at number one worldwide... So we're definitely going to make another one,' lead actress Milla Jovovich gushes about the possible follow-up.
The blonde girl reprises her 'Resident Evil: Extinction' role as K-Mart, while the actor is recruited as new cast member to portray Luther West.
Milla Jovovich and very pregnant Ali Larter chose sparkling dresses, while Wentworth Miller looked tidy in black outfit when attending the world premiere on September 2.
Ali Larter's Claire Redfield has a duel with Executioner Majini in this new snippet, which features heart-pumping music.
Alice who is jumping from a rooftop and having a hard landing are some of the things previewed in the new sneak peeks.
Titled 'the Axe-Man', the scene which is introduced by director Paul W.S. Anderson takes place in a shower room and sees Alice as well as Claire fighting the masked character.
In the short clip, the man behind the Umbrella Corporation is seen knocking out Claire and Chris Redfield in just several moves.
It mostly gives preview to action scenes involving Milla Jovovich as her character Alice battles the Umbrella Corporation.
Director Paul W.S. Anderson says there have been no official plans to make another 'Resident Evil' film but he has an idea to bring Leon S. Kennedy to the next installment.
Highly-anticipated projects such as 'Harry Potter and the Deathly Hallows' and 'Thor' will fill the Saturday panels, while the last day of the convention is dedicated to kids.
While Alice shares what she should do to survive the apocalypse, fresh scenes are displayed in the new trailer.