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The 3D Animation Disney film successful in topping the chart, followed by 'Hall Pass' in second place and 'Unknown (2011)' in the third.
Lending their voice for the film's characters, the two stars join forces to promote the movie with Elton John who has his songs featured in it.
Take a look at how a Shakespeare's play is turned into an animation with a comical off-the-wall makeover.
The 'Devil Wears Prada' actress has been in talks to fill in the vacant role of Juliet which has been left by Kate Winslet earlier.
"Gnomeo & Juliet," an animated musical based on William Shakespeare's tragic romance, is no longer in production at Walt Disney Feature Animation