"Descender" is described as a sprawling space opera odyssey about a little boy looking for home in a universe that hates and fears him. The incredibly lifelike artificial boy, TIM-21, might hold the secrets deep in his machine DNA to the origin of robots that have decimated entire planets.

As a result, he is the most-wanted robot in the universe. Before long the entire galaxy is looking for TIM-21 and his ragtag group of unlikely companions, as they make their way from one exotic planet to the next with new foes advancing on them at every turn.