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Grossing $22.4 million, the Steven Soderbergh-directed movie knocks down last week's chart-topper 'The Help' and another newcomer 'Warrior'.
The Beth Emhoff depicter dressed elegantly in a blush pink organza gown, while her male co-star appeared in a traditional two-piece suit.
In this sci-fi thriller, Gwyneth Paltrow is among the first people who get infected by a virus that causes a worldwide pandemic.
Filming his scene on the streets in San Francisco, California, the actor is snapped covering his body with a plastic outfit from above the waist.
The studio has also set release dates for the follow-up to 'Valentine's Day', 'Contagion', 'Red Riding Hood' and many others.
The 'Two Lovers' beauty joins the sci-fi thriller which already has the 'Titanic' actress and Jude Law among the cast.
Additionally, Jude Law and Marion Cotillard have also signed to star in the Steven Soderbergh-directed movie.