| Rank | Week-1 | Movie Title | Total Gross | ||
| 1 |
|
|
 Iron ManRobert Downey Jr., Terrence Howard
|
$102,118,668 | $102,118,668 |
| 2 |
|
|
Made of HonorPatrick Dempsey, Michelle Monaghan
|
$14,756,850 | $14,756,850 |
| 3 |
 |
|
Baby MamaTina Fey, Amy Poehler
|
$10,065,010 | $32,062,480 |
| 4 |
|
|
Harold & Kumar Escape from Guantanamo BayKal Penn, John Cho
|
$6,114,373 | $25,369,337 |
| 5 |
|
|
Forgetting Sarah MarshallJason Segel, Kristen Bell
|
$6,059,920 | $44,732,340 |
| 6 |
|
|
The Forbidden KingdomJet Li, Jackie Chan
|
$4,187,897 | $45,112,303 |
| 7 |
|
|
Nim's IslandAbigail Breslin, Jodie Foster
|
$2,677,543 | $42,471,660 |
| 8 |
|
|
Prom NightBrittany Snow, Johnathon Schaech
|
$2,403,313 | $41,350,731 |
| 9 |
|
|
21Jim Sturgess, Kate Bosworth
|
$2,002,471 | $78,959,237 |
| 10 |
|
|
88 MinutesAl Pacino, Alicia Witt
|
$1,545,084 | $15,368,925 |
| 11 |
|
|
Horton Hears a Who!Jim Carrey, Steve Carell
|
$1,337,562 | $149,817,680 |
| 12 |
|
|
DeceptionEwan McGregor, Hugh Jackman
|
$883,417 | $4,000,654 |
| 13 |
 |
|
Drillbit TaylorOwen Wilson, Leslie Mann
|
$730,231 | $31,164,888 |
| 14 |
|
|
Street KingsKeanu Reeves, Forest Whitaker
|
$708,142 | $25,133,327 |
| 15 |
|
|
Expelled: No Intelligence AllowedBen Stein, Jason Collett
|
$678,304 | $6,613,256 |
| 16 |
|
|
The VisitorRichard Jenkins, Haaz Sleiman
|
$606,597 | $1,576,256 |
| 17 |
|
|
LeatherheadsGeorge Clooney, Renee Zellweger
|
$572,320 | $30,332,745 |
| 18 |
|
|
Smart PeopleDennis Quaid, Sarah Jessica Parker
|
$325,787 | $8,943,977 |
| 19 |
|
|
Young@HeartJim Armenti, William E. Arnold Jr.
|
$315,357 | $925,669 |
| 20 |
|
|
Shine a LightMick Jagger, Keith Richards
|
$278,006 | $4,846,348 |
