The story follows best friends Nick and Tree, two vampires that have been inseparable party fiends for over a thousand years. Together they've smoked opium with Genghis Khan, had orgies in Michelangelo's studio, and even fronted a death metal band.
Now, after centuries together, a mid-life crisis threatens to send them on their separate ways. That is, until, a megalomaniac with an apocalypse fetish threatens to end the human race, forcing the once BFFs to stick together to save the world.