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Jackson and Reilly are being considered by Universal Pictures to replace recently-exiting actors J.K. Simmons and Michael Keaton while Wilkinson is circling another lead role.
The upcoming project which is directed by Oliver Stone is eyeing the three actors after previously landing Joseph Gordon-Levitt and Shailene Woodley for the drama.
The two stars, along with Alexandra Daddario and Tom Wilkinson, will join Benjamin Walker and Teresa Walker in the romance drama.
Lucrezia learns how to please her future spouse, but the Borgias' tawdry behavior sullies her lavish nuptials.
Michael J. Fox reunited with his 'Family Ties' co-stars when receiving the Fan Favorite Award from comedian Ben Stiller.
Lead star Robin Wright Penn attended the first theatrical screening supported by James McAvoy, Evan Rachel Wood, and Alexis Bledel among others.