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Malik could not join his bandmates on the NBC show because of stomach bug, but host Matt Lauer asked the other boys if Malik's absence was related to drugs.
The British/Irish boyband performs some of their biggest hits and the new singles off their new 'FOUR' album without Malik who has a stomach issue.
The British/Irish boyband promises that 'FOUR', set for November 17, will be their 'most different sounding album.'
Sam Smith, Chris Martin, Rita Ora, Ellie Goulding and Bono are other stars recording a new version of 'Do They Know It's Christmas?' to help raise funds to fight Ebola.
The song, penned by Jamie Scott who previously worked with the boys on 'Story of My Life', is the second single off the group's upcoming 'FOUR' album.
Harry Styles says he congratulated the Duchess of Cambridge on 'the bump,' although she 'didn't look bumpy,' while Liam Payne admits he was really nervous.
Supporting the launch of the boyband's latest album, the one-hour special would be their first TV special in the United States.
The boys recall the first time they fell in love with someone on the latest promo track off their upcoming 'FOUR' album.
The boys sing about winning back a former lover on the song, which is available to fans who have pre-ordered the album scheduled for next week.
It was a big night for big nominee Grande who kicked off the event with a performance of 'Problem' and bagged a nod for the song.
Also announced as an AMA performer is Garth Brooks, who will sing a track off his new album from a stop on his ongoing tour.
The group shared the new song on iTunes after getting 40,000 Twitter retweets, 40,000 Facebook shares, 4,000 Instagram comments and 4,000 Tumblr reblogs from fans who pre-ordered the LP.
While it's still unclear what Lorde will sing at the event, Fergie will deliver a live performance of 'L.A. LOVE (la la)' and 1D will sing a song from their 'FOUR' album.
The bizarre music video finds the five boys partying with sumo wrestlers, a marching band and a sunglasses-wearing chimpanzee in a desert.
Harry Styles and his bandmates are bringing their latest tour to Europe and North America summer next year.