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The couple announces via their Twitter accounts that they are expecting their first child together.
Odette Yustman, who portrayed Annie in some episodes of the canceled show, will play a new doctor in House's team.
In a statement, the 55-year-old actor revealed that his girlfriend Kayte Walsh lost their unborn child about six weeks ago and the mourning couple asked a little time to heal.
The longtime couple exchanged vows in an outdoor ceremony in Ojai, California on Sunday, October 10 with 215 family members and friends witnessing their union.
The two were additionally joined by Sigourney Weaver, Jamie Lee Curtis and Betty White to promote their film at the September 22 event.
Odette Yustman will be guest starring in an episode as the love interest of Justin Walker, the character played by Annable.
In a new Funny or Die video to promote upcoming comedy movie 'You Again', the four actresses are seen having a fight because of Kristen's tendency to keep talking on and on during the chat.