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All three actors will lend their voice in a January outing that also has Will Arnett, Leslie Mann and Seth Rogen as guest stars.
Judd Apatow, Rob Reiner and Mel Brooks will kick off the five-day event where comedians can tweet jokes and post videos using the hashtag #ComedyFest.
The executive producer says that they're preparing to start filming the third season of the Lena Dunham-starring HBO comedy series.
Words are, the 'Grey's Anatomy' star comes to the rescue of the young driver with a crowbar in hand after the boy crashed his car into the actor's front yard in Malibu, California.
Returning as Pete and Debbie respectively, 'Knocked Up' stars Paul Rudd and Leslie Mann are dealing with new problems in their middle-age marriage life.
In tribute to American Jewish World Service and the organization president's 70th birthday, Apatow directs a comedy video which would be debuted on October 28.
The 'Mummy' star admits that she hasn't been called by the filmaker whom she worships, believing that it is all because she was very intense about her passion for him during their latest meeting.