(*): W=Win, N=Nomination
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Performance by an actress in a supporting role | The Sessions (2012) | - |
| 1998 | W | Best Actress in a Leading Role | As Good as It Gets (1997) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1997 | N | Best Actress | Twister (1996) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | N | Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication | Mad About You (1992) (TV) | - |
| 1998 | W | Funniest Actress in a Motion Picture (Leading Role) | As Good as It Gets (1997) | - |
| 1996 | W | Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication | Mad About You (1992) (TV) | - |
| 1995 | W | Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication | Mad About You (1992) (TV) | - |
| 1994 | W | Funniest Female Performer in a TV Series (Leading Role) Network, Cable or Syndication | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | W | Favorite Actress - Comedy/Romance | What Women Want (2000) | - |
| 2001 | W | Favorite Supporting Actress - Drama | Cast Away (2000) | - |
| 2001 | N | Favorite Actress - Drama/Romance | Pay It Forward (2000) | - |
| 1999 | W | Favorite Actress - Video | As Good as It Gets (1997) | - |
| 1997 | W | Favorite Actress - Action/Adventure | Twister (1996) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Best Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | W | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| 1998 | W | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| 1997 | W | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| 1997 | N | Outstanding Comedy Series | Mad About You (1992) (TV) | Larry Charles (executive producer), Danny Jacobson (executive producer), Robert Heath (producer) |
| 1996 | W | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| 1995 | N | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| 1994 | N | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| 1993 | N | Outstanding Lead Actress in a Comedy Series | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1998 | W | Best Actress | As Good as It Gets (1997) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Best Performance by an Actress in a Supporting Role in a Motion Picture | The Sessions (2012) | - |
| 1998 | W | Best Performance by an Actress in a Motion Picture - Comedy/Musical | As Good as It Gets (1997) | - |
| 1998 | N | Best Performance by an Actress in a TV-Series - Comedy/Musical | Mad About You (1992) (TV) | - |
| 1997 | W | Best Performance by an Actress in a TV-Series - Comedy/Musical | Mad About You (1992) (TV) | - |
| 1996 | N | Best Performance by an Actress in a TV-Series - Comedy/Musical | Mad About You (1992) (TV) | - |
| 1995 | W | Best Performance by an Actress in a TV-Series - Comedy/Musical | Mad About You (1992) (TV) | - |
| 1994 | W | Best Performance by an Actress in a TV-Series - Comedy/Musical | Mad About You (1992) (TV) | - |
| 1993 | N | Best Performance by an Actress in a TV-Series - Comedy/Musical | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | W | Outstanding Supporting Actress - Drama Special | Empire Falls (2005) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2006 | W | Ensemble of the Year | Bobby (2006) | Ashton Kutcher, Heather Graham, Shia LaBeouf, Demi Moore |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | W | Best Supporting Female | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Actress of the Year | The Sessions (2012) | - |
| 2010 | N | British Actress of the Year | The Last Station (2009) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2001 | N | Best Kiss | Cast Away (2000) | Tom Hanks |
| 1998 | N | Best Female Performance | As Good as It Gets (1997) | - |
| 1997 | N | Best Female Performance | Twister (1996) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | W | - | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | W | Favorite Female Television Performer | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Best Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Actress in a Supporting Role | The Sessions (2012) | - |
| 1999 | N | Best Performance by an Actress in a Television Series - Comedy or Musical | Mad About You (1992) (TV) | - |
| 1998 | W | Best Performance by an Actress in a Motion Picture - Comedy or Musical | Mad About You (1992) (TV) | - |
| 1998 | N | Best Performance by an Actress in a Television Series - Comedy or Musical | Mad About You (1992) (TV) | - |
| 1997 | N | Best Performance by an Actress in a Television Series - Musical or Comedy | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Outstanding Performance by a Female Actor in a Supporting Role | The Sessions (2012) | - |
| 2007 | N | Outstanding Performance by a Cast in a Motion Picture | Bobby (2006) | Anthony Hopkins, Demi Moore, Christian Slater |
| 1998 | W | Outstanding Performance by a Female Actor in a Leading Role | As Good as It Gets (1997) | - |
| 1998 | N | Outstanding Performance by a Female Actor in a Comedy Series | Mad About You (1992) (TV) | - |
| 1998 | N | Outstanding Performance by an Ensemble in a Comedy Series | Mad About You (1992) (TV) | Robin Bartlett, Cynthia Harris, Leila Kenzle |
| 1997 | N | Outstanding Performance by a Female Actor in a Comedy Series | Mad About You (1992) (TV) | - |
| 1997 | N | Outstanding Performance by an Ensemble in a Comedy Series | Mad About You (1992) (TV) | Leila Kenzle, John Pankow, Anne Ramsay |
| 1996 | N | Outstanding Performance by a Female Actor in a Comedy Series | Mad About You (1992) (TV) | - |
| 1995 | W | Outstanding Performance by a Female Actor in a Comedy Series | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2008 | W | Breakthrough Director of the Year | - | - |
| 1998 | W | Actress of the Year | - | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | W | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1999 | N | Favorite Actress in a Comedy | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2013 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 1998 | N | Best Actress in a Quality Comedy Series | Mad About You (1992) (TV) | - |
| 1997 | W | Best Actress in a Quality Comedy Series | Mad About You (1992) (TV) | - |
| 1996 | W | Best Actress in a Quality Comedy Series | Mad About You (1992) (TV) | - |
| 1994 | W | Best Actress in a Quality Comedy Series | Mad About You (1992) (TV) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | N | Best Supporting Actress | The Sessions (2012) | - |
| Year | * | Category | Works | Shared |
|---|---|---|---|---|
| 2012 | W | Career Achievement Award | - | - |
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