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Back in 2013, the 70-year-old actor and filmmaker made headlines after suggesting that his throat cancer could have been caused by oral sex.
Zeta-Jones is tapped to play a journalist who causes rift and suspicion, while Gambon will play one of the Home Guard members.
In the biopic, she will be Colombian woman Griselda Blanco who was an important member of the Medellin Cartel.
The couple, who announced separation a few months ago, are said trying hard to fix their marriage by spending time together.
During an appearance on 'Tonight Show with Jay Leno', the 'Behind the Candelabra' actor says that his relationship with his estranged wife 'should hopefully be on the up and up.'
Zeta-Jones says during the NYC Dance Alliance Foundation Gala in New York City that Michael's Emmy win 'was wonderful - so well-deserved.'
The 'Behind the Candelabra' actor, who previously announced that he and his wife were 'taking a break,' said prior to the Emmys that he and Zeta-Jones were 'going to work things out.'
The 'Behind the Candelabra' actor says his separation from his actress wife is exaggerated, denying marriage crisis rumors.
Rumor has it, the stress of dealing with his cancer and her bipolar disorder becomes too much for the 'Haywire' actor and the 'Rock of Ages' actress.
The 'Red 2' actress talks about how she coped with her husband's cancer diagnosis and its impact on her.
The wife of Michael Douglas 'is committed to periodic care in order to manage her health in an optimum manner.'
Barbra Streisand and Norah Jones also showcase their impeccable vocals on the Sunday's Academy Awards night.
The three past Oscar winners will perform in a special Oscars tribute to movie musicals during the awards ceremony on Sunday, February 24.
The Velma Kelly of 'Chicago' plays the upcoming musical movie's villain who wants to shut down rock 'n roll in Los Angeles.
Country music star Shania Twain's vocal problems became so bad following the break-up of her marriage to producer Mutt Lange, she couldn't even sing in the shower.